ANTIGENIC PROPERTIES OF NATIVE AND REGENERATED HORSE SERUM ALBUMIN
نویسندگان
چکیده
منابع مشابه
Antigenic Properties of Native and Regenerated Horse Serum Albumin
Comparative immunological measurements have been carried out on crystalline horse serum albumin in the native state and after regeneration from 8 M urea solutions. The mean antigenic activity of the regenerated protein has been found to be less than 10 per cent of that of the native, whereas both antigens proved to be immunologically equivalent. The problem of the relation between protein denat...
متن کاملAntigenic Properties of Native and Regenerated Horse Serum Albumin*$ by John O. Erickson
One of the characteristic manifestations of biological activity of proteins resides in their ability to elicit antibody formation. While the activity of certain immune bodies, as well as that of enzymes, or viruses, is known to be destroyed by processes causing protein denaturation, the relation between denaturation and antigenicity is only vaguely understood. I t has been reported that denatur...
متن کاملNative and Regenerated Bovine Albumin
1. The effects of regeneration of whole bovine albumin on antigenic activity and serological specificity were determined by precipitin measurements on rabbit antisera to (1) native whole albumin, (2) albumin regenerated from 8 M urea, and (3) albumin regenerated from 8 M guanidine hydrochloride. 2. While numerically the mean antibody response to these three antigens was found to decrease in the...
متن کاملImmunochemical Properties of Native and Denatured Horse Serum Globulins
1. The influence of guanidine hydrochloride on the denaturation and regeneration of Type I antipneumococcal horse serum globulin was determined by measurements of viscosity, diffusion, and sedimentation in the ultracentrifuge. In addition, the effect of NaCNS on the antibody globulin was studied. 2. Both the irreversibly denatured and the regenerated fractions were found to be precipitable by S...
متن کاملImmunochemical Properties of Native and Denatured Horse Serum
The problem of the relation of antibodies to normal serum globulins has been approached in the past by comparison of their chemical, physical, and immunological properties in the native state (cf. 1-3). Little information is available, however, on their relative behavior in the denatured state. This paper describes an investigation of the effects of denaturation by guanidine hydrochloride on ce...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1943
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.78.1.1